I’ve just mailed Sarabian a bit of advice on how I set up Pyblosxom websites. Note that this is probably pretty specific to me, but I present the advice below anyway in case it’s useful to someone else:
I tend to set it up like this: /var/www/example.org /html /pyblosxom /pyblosxom.cgi /config.py /.htaccess  /pyblosxom /Pyblosxom  /plugins  /sites /blogging-hacks
 content is:
Then set, in config.py, py[‘datadir‘]=‘/var/www/example.org/sites‘, py[‘plugins\_dir‘]=‘/var/www/example.org/plugins‘, and set the base (the thing which tells it where Pyblosxom itself is, I can’t remember) to /var/www/example.org/pyblosxom. Then set up an Apache rewrite rule, something like RewriteRule /weblogs(.*) /pyblosxom/pyblosxom.cgi$1 and then it should all work.